By Joseph W. St. Geme III
This ebook describes the starting to be physique of knowledge at the epidemiology, scientific manifestations, transmission, pathogenesis, analysis, and therapy of Kingella kingae infectionsin kids. moreover, it covers experimental equipment which were constructed to review the microbiology, genetics, and virulence elements of K. kingae, details that gives the root for brand spanking new methods to remedy and prevention of K. kingae disease. With this content material in brain, excerpts from the booklet could be of relevance for clinicians who take care of pediatric sufferers, for scientific microbiologists who're fascinated by detecting organisms in medical specimens, and for scientists who're learning K. kingae in an attempt to enhance novel ambitions for antimicrobial treatment and new techniques to prevention.
First remoted within the Nineteen Sixties via Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae used to be mostly neglected over the subsequent twenty years as a human pathogen due to its unusual restoration from sufferers with disorder. notwithstanding, lately K. kingae has been more and more famous as a clinically vital pathogen in teenagers, and is at the moment well-known because the major reason behind osteoarticular infections in teenagers in an increasing number of international locations. study into this organism has grown vastly during the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of sickness.
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Extra info for Advances in Understanding Kingella kingae
Adherence by this mutant can be restored by eliminating capsule expression, uncovering Knh, and allowing Knh access to host cell receptors . While not demonstrated experimentally, it is likely that the polysaccharide capsule is also able to mask other surface antigens, many of which are smaller than Knh. In addition to the outer membrane-associated polysaccharide capsule, K. kingae has also been found to secrete a galactofuranose exopolysaccharide homopolymer called PAM galactan. Bendaoud et al.
Pediatr Int 57(4):805–806. 12685 33. Ceroni D, Merlini L, Salvo D, Lascombes P, Dubois-Ferriere V (2013) Pyogenic flexor tenosynovitis of the ﬁnger due to Kingella kingae. Pediatr Infect Dis J 32(6):702–703 (United States). 0b013e3182868f17 34. Ferroni A, Al Khoury H, Dana C, Quesne G, Berche P, Glorion C, Pejin Z (2013) Prospective survey of acute osteoarticular infections in a French paediatric orthopedic surgery unit. Clin Microbiol Infect 19(9):822–828. 12031 35. Ceroni D, Cherkaoui A, Ferey S, Kaelin A, Schrenzel J (2010) Kingella kingae osteoarticular infections in young children: clinical features and contribution of a new speciﬁc real-time PCR assay to the diagnosis.
Kingae virulence factor. Further study by Starr et al.  established that the genetic requirements for encapsulation in K. kingae include the predicted ctrABCD export operon, lipA, lipB, Fig. 3 Transmission electron micrographs of thin-sectioned cationic ferritin-stained wild-type K. kingae strain 269–492 (a) and an isogenic ctrA capsule export mutant (b). A layer of electron density due the cationic ferritin interactions with the surface capsular polysaccharide is visible on the surface of the wild-type strain (a) but is absent from the nonencapsulated ctrA mutant (b).