Download Advances in Understanding Kingella kingae by Joseph W. St. Geme III PDF

By Joseph W. St. Geme III

This ebook describes the starting to be physique of knowledge at the epidemiology, scientific manifestations, transmission, pathogenesis, analysis, and therapy of Kingella kingae infectionsin kids. moreover, it covers experimental equipment which were constructed to review the microbiology, genetics, and virulence elements of K. kingae, details that gives the root for brand spanking new methods to remedy and prevention of K. kingae disease. With this content material in brain, excerpts from the booklet could be of relevance for clinicians who take care of pediatric sufferers, for scientific microbiologists who're fascinated by detecting organisms in medical specimens, and for scientists who're learning K. kingae in an attempt to enhance novel ambitions for antimicrobial treatment and new techniques to prevention.

First remoted within the Nineteen Sixties via Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae used to be mostly neglected over the subsequent twenty years as a human pathogen due to its unusual restoration from sufferers with disorder. notwithstanding, lately K. kingae has been more and more famous as a clinically vital pathogen in teenagers, and is at the moment well-known because the major reason behind osteoarticular infections in teenagers in an increasing number of international locations. study into this organism has grown vastly during the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of sickness.

Show description

Read Online or Download Advances in Understanding Kingella kingae PDF

Similar epidemiology books

The Chimp and the River: How AIDS Emerged from an African Forest

The true tale of AIDS—how it originated with an outbreak in a chimpanzee, jumped to 1 human, after which contaminated greater than 60 million people—is very varied from what so much people imagine we all know. contemporary examine has published darkish surprises and yielded a considerably new situation of ways AIDS all started and unfold.

Global Health in Africa: Historical Perspectives on Disease Control (Perspectives on Global Health)

Worldwide healthiness in Africa is a primary exploration of chosen histories of world well-being tasks in Africa. the gathering addresses probably the most vital interventions in illness keep watch over, together with mass vaccination, large-scale therapy and/or prophylaxis campaigns, damage aid efforts, and dietary and virological examine.

The Fictional Republic: Horatio Alger and American Political Discourse

Investigating the endurance and position of the formulation of Horatio Alger in American politics, the fictitious Republic reassesses the Alger tale in its Gilded Age context. Carol Nackenoff argues that Alger was once a prepared observer of the dislocations and financial pitfalls of the quickly industrializing kingdom, and devised a suite of symbols that addressed anxieties approximately energy and id.

The World's Health Care Crisis: From the Laboratory Bench to the Patient's Bedside

At the present, human society is dealing with a future health care hindrance that affects sufferers world wide. within the usa, it's quite often believed that the most important challenge is loss of reasonable entry to overall healthiness care (i. e. healthiness insurance). This booklet takes an extraordinary method of handle this factor via featuring that the main challenge isn't loss of reasonable entry to health and wellbeing care consistent with se, yet loss of entry to higher, more secure, and cheaper medications.

Extra info for Advances in Understanding Kingella kingae

Sample text

Adherence by this mutant can be restored by eliminating capsule expression, uncovering Knh, and allowing Knh access to host cell receptors [20]. While not demonstrated experimentally, it is likely that the polysaccharide capsule is also able to mask other surface antigens, many of which are smaller than Knh. In addition to the outer membrane-associated polysaccharide capsule, K. kingae has also been found to secrete a galactofuranose exopolysaccharide homopolymer called PAM galactan. Bendaoud et al.

Pediatr Int 57(4):805–806. 12685 33. Ceroni D, Merlini L, Salvo D, Lascombes P, Dubois-Ferriere V (2013) Pyogenic flexor tenosynovitis of the finger due to Kingella kingae. Pediatr Infect Dis J 32(6):702–703 (United States). 0b013e3182868f17 34. Ferroni A, Al Khoury H, Dana C, Quesne G, Berche P, Glorion C, Pejin Z (2013) Prospective survey of acute osteoarticular infections in a French paediatric orthopedic surgery unit. Clin Microbiol Infect 19(9):822–828. 12031 35. Ceroni D, Cherkaoui A, Ferey S, Kaelin A, Schrenzel J (2010) Kingella kingae osteoarticular infections in young children: clinical features and contribution of a new specific real-time PCR assay to the diagnosis.

Kingae virulence factor. Further study by Starr et al. [44] established that the genetic requirements for encapsulation in K. kingae include the predicted ctrABCD export operon, lipA, lipB, Fig. 3 Transmission electron micrographs of thin-sectioned cationic ferritin-stained wild-type K. kingae strain 269–492 (a) and an isogenic ctrA capsule export mutant (b). A layer of electron density due the cationic ferritin interactions with the surface capsular polysaccharide is visible on the surface of the wild-type strain (a) but is absent from the nonencapsulated ctrA mutant (b).

Download PDF sample

Rated 4.09 of 5 – based on 29 votes